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NCBI: db=pubmed; Term=adrenal tumor
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Primary pleomorphic rhabdomyosarcoma of the adrenal gland in an adult: A case report.

Mon, 12/23/2013 - 15:41
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Primary pleomorphic rhabdomyosarcoma of the adrenal gland in an adult: A case report.

Oncol Lett. 2014 Jan;7(1):137-139

Authors: Wang CJ, Li J, Qin J

Abstract
A 61-year-old female was referred to The First Affiliated Hospital, College of Medicine, Zhejiang University (Hangzhou, China) due to a right adrenal tumor. A pre-operative transcutaneous fine-needle aspiration biopsy and right adrenalectomy were performed, and pathological analysis resulted in the diagnosis of pleomorphic rhabdomyosarcoma (RMS). Primary pleomorphic RMS of the adrenal gland in an adult is a rare condition. To the best of our knowledge, this is the first case of pleomorphic RMS of the adrenal gland in an adult diagnosed by light microscopy and immunohistochemical stains.

PMID: 24348835 [PubMed - as supplied by publisher]

Mass-array screening of frequent mutations in cancers reveals RB1 alterations in aggressive adrenocortical carcinomas.

Mon, 12/23/2013 - 15:41
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Mass-array screening of frequent mutations in cancers reveals RB1 alterations in aggressive adrenocortical carcinomas.

Eur J Endocrinol. 2013 Dec 17;

Authors: Ragazzon B, Libé R, Assie G, Tissier F, Barreau O, Houdayer C, Perlemoine K, Audebourg A, Clauser E, Rene-Corail F, Bertagna X, Dousset B, Bertherat J, Groussin L

Abstract
CONTEXT: adrenocortical carcinoma (ACC) is a rare disease with a poor overall outcome. Transcriptome analysis identified two groups of ACCs with different prognosis. In aggressive ACCs, somatic mutations of the tumor suppressor gene TP53 and the proto-oncogene β-catenin are detected in 50% of cases. For the remaining aggressive ACCs and for the group with a better prognosis, molecular alterations are unknown.
OBJECTIVE: to identify new molecular actors driving adrenal tumorigenesis.
EXPERIMENTAL DESIGN: analysis by mass-array of 374 mutations among 32 common oncogenes or tumor suppressor genes was performed on the tumoral DNA of 26 ACCs, using Sequenom® OncoCarta™ Panels.
RESULTS: four mutations were identified, two previously known β-catenin mutations and one alteration in two other genes: Janus Kinase 3 (JAK3) and retinoblastoma gene (RB1). The JAK3 alteration was found in leukocyte DNA and therefore considered as a polymorphism and not a somatic event. The full RB1 tumor suppressor gene was subsequently sequenced in a cohort of 49 ACCs (26 ACCs from the "OncoCarta cohort" and 23 other ACCs): three somatic mutations were identified, all in the poor outcome ACC group. By immunohistochemistry, a loss of the retinoblastoma protein (pRb) was found exclusively in aggressive ACCs in 27% of cases (7 out of 26), three of them with an inactivating RB1 mutation. Among the seven pRb negative ACCs, five had an allele loss at the RB1 locus.
CONCLUSIONS: parallel analysis of somatic mutations among known cancer genes allowed us to identify RB1 as a new actor in aggressive ACCs. These results suggest a prognostic significance of pRb expression loss in ACCs.

PMID: 24347427 [PubMed - as supplied by publisher]

Biochemical diagnosis of phaeochromocytoma and paraganglioma.

Mon, 12/23/2013 - 15:41
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Biochemical diagnosis of phaeochromocytoma and paraganglioma.

Eur J Endocrinol. 2013 Dec 17;

Authors: van Berkel A, Lenders J, Timmers HJ

Abstract
Adrenal phaechromocytomas and extra-adrenal sympathetic paragangliomas (PPGLs) are rare neuroendocrine tumours characterised by production of the catecholamines noradrenaline, adrenaline and dopamine. Tumoural secretion of catecholamines determines their clinical presentation which is highly variable among patients. Up to 10-15% of patients present entirely asymptomatically and in 5% of all adrenal incidentalomas a PPGL is found. Therefore, prompt diagnosis of PPGL remains a challenge for every clinician. Early consideration of the presence of a PPGL is of utmost importance since missing the diagnosis can be devastating due to potential lethal cardiovascular complications of disease. First step in diagnosis is proper biochemical analysis to confirm or refute the presence of excess production of catecholamines or their metabolites. Biochemical testing is not only indicated in symptomatic patients, but also in asymptomatic patients with adrenal incidentalomas or identified genetic predispositions. Measurements of metanephrines in plasma or urine offers the best diagnostic performance and are the tests of first choice. Paying attention to sampling conditions, patient preparation and use of interfering medications is important since these factors can largely influence test results. When initial test results are inconclusive, additional tests can performed such as the clonidine suppression test. Test results can also be used for estimation of tumour size or prediction of tumor location and underlying genotype. Furthermore, tumoural production of 3-methoxytyramine is associated with presence of an underlying SDHB mutation and may be a biomarker of malignancy.

PMID: 24347425 [PubMed - as supplied by publisher]

Cutaneous leiomyomatosis in a mother and daughter>.

Mon, 12/23/2013 - 15:41
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Cutaneous leiomyomatosis in a mother and daughter>.

An Bras Dermatol. 2013 Nov-Dec;88(6 Suppl 1):124-7

Authors: Lencastre A, Cabete J, Gonçalves R, João A, Fidalgo A

Abstract
A 34-year-old woman with no known medical history was evaluated for multiple painful brown nodules and papules on the anterior aspect of the trunk. She mentioned a history of similar cutaneous findings on her mother. Biopsies of three lesions revealed piloleiomyomata. Renal and adrenal ultrasound revealed an isolated simple cortical cyst, and pelvic and endovaginal ultrasound revealed two uterine myomata. The clinical diagnosis of hereditary leiomyomatosis and renal cell cancer was corroborated by the identification of a heterozygous variant on exon 5 of the fumarate hydratase gene (c.578C>T p.T193I). Identification of the tumor piloleiomyoma should alert the dermatologist to this rare genodermatosis, which is associated with an increased risk of renal cell tumors, demanding multidisciplinary follow-up, and personal and family counseling.

PMID: 24346898 [PubMed - in process]

Unmasked renal impairment and prolonged hyperkalemia after unilateral adrenalectomy for primary aldosteronism coexisting with primary hyperparathyroidism: report of a case.

Mon, 12/23/2013 - 15:41
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Unmasked renal impairment and prolonged hyperkalemia after unilateral adrenalectomy for primary aldosteronism coexisting with primary hyperparathyroidism: report of a case.

Surg Today. 2013 Dec 17;

Authors: Hibi Y, Hayakawa N, Hasegawa M, Ogawa K, Shimizu Y, Shibata M, Kagawa C, Mizuno Y, Yuzawa Y, Itoh M, Iwase K

Abstract
We herein report the case of a patient with critical hyperkalemia after unilateral adrenalectomy (ADX) for aldosterone-producing adenomas, which were coexisting with primary hyperparathyroidism. A right adrenal tumor oversecreting mineral corticoid was identified in a 62-year-old female whose kidney function had been impaired due to primary hyperaldosteronism and hyperparathyroidism. The ADX improved her hypertension with normalization of the plasma aldosterone concentration, but without adequately increasing her plasma renin activity. Her eGFR further decreased postoperatively, hyperkalemia appeared and the serum potassium level rose to 6.3 mEq/L at 3 months after ADX. Then, treatment with calcium polystyrene sulfonate jelly was started. Eight months after ADX, a left lower parathyroidectomy was performed, and the serum calcium and intact parathyroid hormone levels decreased to the normal range. The hyperkalemia was difficult to control within 20 months postoperatively without treatment with calcium polystyrene sulfonate jelly or hydrocortisone. This suggests that unmasking the renal impairment and relative hypoaldosteronism after ADX might induce critical hyperkalemia.

PMID: 24343173 [PubMed - as supplied by publisher]

A Five-Year Survivor without Recurrence Following Robotic Anterior Radical Antegrade Modular Pancreatosplenectomy for a Well-Selected Left-Sided Pancreatic Cancer.

Mon, 12/23/2013 - 15:41
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A Five-Year Survivor without Recurrence Following Robotic Anterior Radical Antegrade Modular Pancreatosplenectomy for a Well-Selected Left-Sided Pancreatic Cancer.

Yonsei Med J. 2014 Jan 1;55(1):276-9

Authors: Han DH, Kang CM, Lee WJ, Chi HS

Abstract
Radical antegrade modular pancreatosplenectomy (RAMPS) is regarded as a reasonable approach for margin-negative and systemic lymph node clearance in left-sided pancreatic cancer. We present a patient with more than 5 years disease-free survival after robotic anterior RAMPS for pancreatic ductal adenocarcinoma in the body of the pancreas. The distal part of pancreas, soft tissue around the celiac trunk, and the origin of splenic vessels was dissected with the underlying fascia between the pancreas and adrenal gland. Resected specimen was removed through small vertical abdominal incision. Robot working time was about 8 hours, and blood loss was about 700 mL without blood transfusion. He returned to an oral diet on the postoperative first day and recovered without any clinically relevant complications. There was no lymph node metastasis, perineural or lymphovascular invasion. Both the pancreatic resection margin and the tangential posterior margin were free of carcinoma. The patient received only postoperative adjuvant radiotherapy around the tumor bed. The patient has survived for more than 5 years without evidence of cancer recurrence. Minimally invasive radical left-sided pancreatectomy with splenectomy may be oncologically feasible in well-selected pancreatic cancer.

PMID: 24339319 [PubMed - in process]

Surgical management of adrenal metastases.

Mon, 12/23/2013 - 15:41
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Surgical management of adrenal metastases.

J Surg Oncol. 2014 Jan;109(1):31-5

Authors: Bradley CT, Strong VE

Abstract
In the presence of a history of cancer, adrenal masses are commonly, but not exclusively, metastases. Depending upon the status of the patient's ongoing cancer therapy, overall tumor burden, and performance score, adrenalectomy is a viable treatment option. Herein we review the prevalence, diagnostic evaluation, and selection for surgical treatment of adrenal metastases. Additional attention is paid to recent data supporting the safety and oncologic efficacy of laparoscopic adrenalectomy. J. Surg. Oncol. 2014 109:31-35. © 2013 Wiley Periodicals, Inc.

PMID: 24338382 [PubMed - in process]

Laparoscopic adrenal metastasectomy: appropriate, safe, and feasible.

Mon, 12/23/2013 - 15:41
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Laparoscopic adrenal metastasectomy: appropriate, safe, and feasible.

Surg Endosc. 2013 Dec 14;

Authors: Chen JY, Ardestani A, Tavakkoli A

Abstract
BACKGROUND: The role of adrenalectomy in management of isolated metastatic adrenal tumors is increasingly established. Laparoscopy is becoming the preferred approach for these resections. We evaluated surgical and oncological outcomes of patients who underwent laparoscopic versus open adrenal metastasectomy and assessed the effect of such surgery on postoperative adjuvant therapy and survival.
METHODS: We reviewed our institutional experience with adult patients who underwent an adrenal metastasectomy from 1997 to 2013. We assessed preoperative tumor size, operating room (OR) time, status of resection margin, and length of stay (LOS), as well as oncological outcomes including the use of adjuvant chemotherapy and radiotherapy within 1 year of surgery and 5-year survival. The χ (2) test, Mann-Whitney U test, and Kaplan-Meier curve were used for statistical analysis.
RESULTS: Thirty-eight patients were identified. Lung was the primary site of malignancy (52.6 % of cases). Of the metastasectomies, 55.2 % (n = 21) were performed laparoscopically and 44.7 % (n = 17) were open. In the laparoscopic group, median tumor size was 2.6 cm versus 4.8 cm in the open group (p = 0.09). Median OR time and complication rates were similar between the 2 groups. The laparoscopic group, however, trended toward a shorter LOS (3 days laparoscopic vs. 4 days for open; p = 0.07). At 1 year, 37 % of all patients had not required any adjuvant chemotherapy or adjuvant radiotherapy.
CONCLUSIONS: This series confirms that adrenal metastasectomy leads to favorable oncological outcomes in select patient groups, with over one-third of patients not requiring adjuvant therapy for at least 1 year after their resection. Laparoscopic approach leads to excellent oncological resection margins without increasing OR time and with a possible reduction in LOS.

PMID: 24337189 [PubMed - as supplied by publisher]

[Various neuroendocrine tumors in a multiple endocrine neoplasia type 1 family].

Mon, 12/23/2013 - 15:41
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[Various neuroendocrine tumors in a multiple endocrine neoplasia type 1 family].

Orv Hetil. 2013 Dec 1;154(51):2037-42

Authors: Sepp K, Valkusz Z

Abstract
When multiple endocrine tumors are detected more tests are required to diagnose endocrine tumor syndromes. The authors report the case history of a patient with clinical manifestation of multiplex endocrine neoplasia type 1 (parathyroid adenoma, pancreatic neuroendocrine tumor, pituitary tumor, adrenal gland tumors and thymic neuroendocrine carcinoma). Genetic screening proved a novel stop codon mutation of the MEN1 gene in the patient and in two other members of the family. The son of the index patient showed clinical symptoms of pancreatic neuroendocrine tumor (insulinoma) and parathyroid adenoma. One of the two daughters was also positive for the same mutation, however, she had no clinical symptoms. The authors review current knowledge on the genetic background of multiple endocrine syndrome type 1, the role of menin and the usefulness of gene mutation screening. Orv. Hetil., 2013, 154(51), 2037-2042.

PMID: 24334135 [PubMed - in process]

Adrenal Myelolipoma: Operative Indications and Outcomes.

Mon, 12/23/2013 - 15:41
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Adrenal Myelolipoma: Operative Indications and Outcomes.

J Laparoendosc Adv Surg Tech A. 2013 Dec 13;

Authors: Gershuni VM, Bittner JG, Moley JF, Brunt LM

Abstract
Abstract Background: Adrenal myelolipoma (AM) is a benign lesion for which adrenalectomy is infrequently indicated. We investigated operative indications and outcomes for AM in a large single-institution series. Subjects and Methods: A retrospective cohort study of prospectively collected data was conducted. Patients (≥16 years of age) who underwent adrenalectomy in the Division of General Surgery at Barnes-Jewish Hospital (1993-2010) were grouped by operative indication (myelolipoma versus other pathology) and compared using nonparametric tests (α<0.05). Results: Sixteen patients (4.0%) had myelolipomas resected out of 402 patients who underwent adrenalectomy. Fourteen patients with suspected AM underwent adrenalectomy, 13 (93%) of whom had AM confirmed on pathology. Indications for adrenalectomy were abdominal or flank pain, large tumor size (>8 cm), atypical radiologic appearance, and/or inferior vena cava compression. Three patients with suspected other adrenal lesions had AM confirmed on final pathology. Operative approach was laparoscopic in 15 cases and open in 1 case of a 21-cm lesion. Patients who underwent laparoscopic adrenalectomy for AM (n=15) or other adrenal pathology (n=343) were similar with respect to age, gender, American Society of Anesthesiologists classification, prior abdominal operation, tumor side, operative time, conversion rate, estimated blood loss, intraoperative complications, hospital length of stay, and 30-day morbidity. However, patients with resected AM had a higher body mass index (36.5±8.1 kg/m(2) versus 30.1±7.5 kg/m(2); P<.01) and a larger preoperative tumor size (8.4±3.0 cm versus 3.1±1.7 cm; P<.01). Conclusions: Laparoscopic adrenalectomy may be appropriate for patients with a presumptive diagnosis of AM and abdominal or flank pain, large tumor size, and/or uncertain diagnosis after imaging. Outcomes and morbidity following LA for AM and other adrenal pathology appear comparable.

PMID: 24328509 [PubMed - as supplied by publisher]

Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring.

Mon, 12/23/2013 - 15:41
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Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring.

Brain Behav Immun. 2013 Dec 8;

Authors: Babri S, Doosti MH, Salari AA

Abstract
There is converging evidence that prenatal maternal infection can increase the risk of occurrence of neuropsychiatric disorders like schizophrenia, autism, anxiety and depression in later life. Experimental studies have shown conflicting effects of prenatal maternal immune activation on anxiety-like behavior and hypothalamic-pituitary-adrenal (HPA) axis development in offspring. We investigated the effects of maternal immune activation during pregnancy on anxiety- and depression-like behaviors in pregnant mice and their offspring to determine whether these effects are dependent on strain. NMRI and C57BL/6 pregnant mice were treated with either saline or lipopolysaccharide on gestational day 17 and then interleukin (IL)-6 and corticosterone (COR) levels; anxiety or depression in the pregnant mice and their offspring were evaluated. The results indicate that maternal inflammation increased the levels of COR and anxiety-like behavior in NMRI pregnant mice, but not in C57BL/6 dams. Our data also demonstrate that maternal inflammation elevated the levels of anxiety-and depression-like behaviors in NMRI offspring on the elevated plus-maze, elevated zero-maze, tail suspension test and forced swimming test respectively, but not in the open field and light-dark box. In addition, we did not find any significant change in anxiety- and depression-like behaviors of adult C57BL/6 offspring. Our findings suggest that prenatal maternal immune activation can alter the HPA axis activity, anxiety- and depression-like behaviors in a strain- and task-dependent manner in offspring and further comprehensive studies are needed to prove the causal relationship between the findings found here and to validate their relevance to neuropsychiatric disorders in humans.

PMID: 24326014 [PubMed - as supplied by publisher]

Malignant paraganglioma of the rectum: The first case report and a review of the literature.

Mon, 12/23/2013 - 15:41
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Malignant paraganglioma of the rectum: The first case report and a review of the literature.

World J Gastroenterol. 2013 Nov 28;19(44):8151-5

Authors: Yu L, Wang J

Abstract
Paragangliomas typically develop in the extra-adrenal sites along the sympathetic and/or the parasympathetic chain. Occasionally, the tumors may arise in some exotic sites, including the head and neck region and the urogenital tract. Paraganglioma presenting as a primary rectal neoplasm has not been well described in the literature. Here, we report the first case of malignant paraganglioma arising in the rectum of a 37-year-old male. He presented to the clinic because of hematochezia with tenesmus. The anorectal digital examination and colonoscopic examination revealed a polypoid mass of the rectum, measuring approximately 4 cm in diameter. The overall morphology and immunophenotype were consistent with a typical paraganglioma. However, the tumor exhibited features suggestive of malignant potential, including local extension into adjacent adipose tissue, nuclear pleomorphism, confluent tumor necrosis, vascular invasion and metastases to regional lymph nodes. In conclusion, we present the first case of rectal malignant paraganglioma. Due to the unexpected occurrence in this region, malignant paraganglioma may be misdiagnosed as other tumors with overlapping features; in particular, a neuroendocrine tumor of epithelial origin. Because of the differences in treatment, separating paraganglioma from its mimics is imperative. Combination of morphology with judicious immunohistochemical study is helpful in obtaining the correct diagnosis.

PMID: 24307812 [PubMed - in process]

Increased bone mineral density in patients with non-alcoholic steatohepatitis.

Mon, 12/23/2013 - 15:41
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Increased bone mineral density in patients with non-alcoholic steatohepatitis.

World J Hepatol. 2013 Nov 27;5(11):627-34

Authors: Kaya M, Işık D, Beştaş R, Evliyaoğlu O, Akpolat V, Büyükbayram H, Kaplan MA

Abstract
AIM: To determine the relationship between non-alcoholic steatohepatitis (NASH) and bone mineral density (BMD).
METHODS: A total of 38 patients (25 males) with a diagnosis of histologically proven NASH and 42 healthy controls (24 males) were enrolled in the study. Demographic features, clinical findings, complete blood count and routine biochemical analysis, as well as adrenal, thyroid and gonadal functions, were recorded. Additionally, intact parathormone, 25-OH-vitamin-D3, tumor necrosis factor-α, interleukin-6, interleukin-1, insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels were measured in both groups. Furthermore, lumbar spine and femoral neck BMD of both groups were measured by the dual-energy X-ray absorptiometry (DXA) method.
RESULTS: The mean age was 41 ± 12 years in the NASH group and 43 ± 11 years in the control group. Among demographic features, waist circumference was significantly larger in the NASH group compared to the control group (P < 0.019). Among laboratory parameters, serum triglyceride (P < 0.008), alanine transaminase (P < 0.0001), aspartate transaminase (P < 0.001), alkaline phosphatase (P < 0.016), gamma glutamyl transferase (P < 0.0001), ferritin (P < 0.001) and 25-OH-vitamin-D3 levels (P < 0.0001) were significantly higher in the NASH group compared to the control group. Lumbar BMD was significantly higher in the NASH group compared to the control group (1.057 ± 0.119 g/cm(2) vs 0.941 ± 0.133 g/cm(2); P < 0.001, respectively). In the NASH group, there was no significant relationship between BMD and fibrosis stage in liver biopsy.
CONCLUSION: NASH increases BMD and may be related to an elevated serum 25-OH-vitamin D3 level.

PMID: 24303091 [PubMed]

Retroperitoneal ganglioneuroma mimicking right adrenal mass.

Mon, 12/23/2013 - 15:41
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Retroperitoneal ganglioneuroma mimicking right adrenal mass.

Urology. 2013 Dec;82(6):e41-2

Authors: Nasseh H, Shahab E

Abstract
Ganglioneuroma is a rare benign tumor of the sympathetic nervous system that can arise from the adrenal medulla. Few reports have been published of the surgical resection of this rare tumor using a laparoscopic approach. We present a case of retroperitoneal ganglioneuroma that mimicked an adrenal mass on imaging and was resected laparoscopically.

PMID: 24295269 [PubMed - in process]

D2 dopamine receptor plays a role in the proliferation of adrenal cortical cells.

Mon, 12/23/2013 - 15:41
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D2 dopamine receptor plays a role in the proliferation of adrenal cortical cells.

J Mol Endocrinol. 2013 Nov 29;

Authors: Chang HW, Huang CY, Wu VC, Yang SY, Chu TS, Chen YM, Hsieh BS, Wu KD

Abstract
Aldosterone-producing adenomas (APA) and bilateral adrenal hyperplasia are the two characteristic types of primary aldosteronism. Dysregulation of adrenal cortical cell proliferation contributes to both diseases. We previously demonstrated that APA tissues express less dopamine D2 receptor (D2R) than the respective non-tumor tissue; this contributes to the overproduction of aldosterone. In this study, we demonstrate that D2R plays a role in the regulation of angiotensin II (AII)-stimulated adrenal cortical cell proliferation. The D2R agonist, bromocriptine, inhibited AII-stimulated cell proliferation in primary cultures of the normal human adrenal cortex and APA. D2R activation attenuated AII-induced PKCμ activation; depletion of PKCμ significantly decreased AII-stimulated cyclin D1 protein expression and cell proliferation. D2R activation also inhibited AII-induced ERK1/2 phosphorylation. Because the less D2R level in APA, less inhibiting effect of D2R on AII signaling made the level of phosphorylated ERK1/2 in APA be significantly greater than and the normal adrenal cortex. Our results demonstrate that in addition to inhibiting aldosterone synthesis/production, D2R also exerts an anti-proliferative effect in adrenal cortical and APA cells by attenuating PKCµ and ERK phosphorylation under AII stimulation. Our novel finding suggests a new therapeutic target for primary aldosteronism.

PMID: 24293642 [PubMed - as supplied by publisher]

Expression and Localization of Neuregulin-1 (Nrg1) and ErbB2/ErbB4 Receptors in Main Endocrine Organs of the Rhesus Monkey.

Thu, 12/19/2013 - 09:04

Expression and Localization of Neuregulin-1 (Nrg1) and ErbB2/ErbB4 Receptors in Main Endocrine Organs of the Rhesus Monkey.

Int J Endocrinol Metab. 2013;11(3):162-6

Authors: Zhao WJ

Abstract
BACKGROUND: Although Neuregulin-1 (Nrg1)and its receptors have been indicated at the mRNA level in partial human endocrine organs and its functional roles have been evaluated in vitro, their morphological distribution in higher animals are not fully studied. The present research focused on expression of Nrg1 and its main receptors ErbB2 and ErbB4 in main endocrine organs of the rhesus monkey.
MATERIALS AND METHODS: The morphological expression of Nrg1 and its receptors ErbB2 and ErbB4 as well as their potential co-localization were determined by double immunofluorescence in the pituitary, thyroid, parathyroid, pancreas and adrenal gland sample tissues. The expression level of Nrg1 on each sample was indexed by the fold of integrative fluorescence intensity (IFI) relative to that of one cortical tissue.
RESULTS: Differential expression of Nrg1 and their cognate receptors ErbB2 and ErbB4 were found selectively expressed in endocrine organs we tested, with higher expression levels detected in the adrenal gland (AG) and pancreas. Co-localization of Nrg1 with either ErbB2 or ErbB4 was detected in AG, thyroid and parathyroid gland, and Nrg1 was only co-localized with ErbB4 in the islet cells of the pancreas. In the pituitary, adjacent localization of Nrg1 positive cells with ErbB4 positive cells were observed.
CONCLUSIONS: This investigation morphologically profiles the differential expression of Nrg1 and its receptors ErbB2 and ErbB4 in the main endocrine organ structures, suggesting an autocrine or paracrine-directed Nrg1-ErbB signaling pathway in some of these structures.

PMID: 24348587 [PubMed]

Testicular mass with intracerebral lesions: malignancy or infection?

Thu, 12/19/2013 - 09:04
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Testicular mass with intracerebral lesions: malignancy or infection?

BMJ Case Rep. 2013;2013

Authors: Prabhudesai SG, Sarkodieh JE, Mankad K

PMID: 23921689 [PubMed - indexed for MEDLINE]

Isolated adrenocorticotropin deficiency associated with painless thyroiditis: a case report and review of the literature.

Thu, 12/19/2013 - 09:04
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Isolated adrenocorticotropin deficiency associated with painless thyroiditis: a case report and review of the literature.

Kurume Med J. 2012;59(3-4):71-7

Authors: Mizokami T, Itoh Y, Sato Y, Nunoi K, Okamura K

Abstract
A 53-year-old Japanese man was admitted with a 3-month history of transient headache followed by general fatigue and weight loss. He had a history of ocular myasthenia gravis which had been in remission following thymectomy 30 years ago. He had a small diffuse goiter without tenderness, and was diagnosed as having painless thyroiditis with mild thyrotoxicosis on admission. Endocrinological studies showed he had isolated adrenocorticotropin deficiency. Magnetic resonance imaging of the pituitary gland revealed no abnormalities. His symptoms improved soon after replacement of glucocorticoid. After an episode of hypothyroidism, he spontaneously became euthyroid. It is likely that thyrotoxicosis uncovered adrenal insufficiency that had developed insidiously, and hypoadrenocorticism-induced immunological changes may have triggered the development of painless thyroiditis. Moreover, thymectomy might have facilitated the development of pituitary and thyroid autoimmunity.

PMID: 23823017 [PubMed - indexed for MEDLINE]

Disseminated avian mycobacteriosis in a free-living grey heron (Ardea cinerea).

Wed, 12/11/2013 - 19:27
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Disseminated avian mycobacteriosis in a free-living grey heron (Ardea cinerea).

Avian Dis. 2013 Sep;57(3):703-6

Authors: Quesada-Canales O, Díaz-Delgado J, Paz Y, Domínguez L, Bezos J, Calabuig P, Suárez-Bonnet A, Fernández A, Andrada M

Abstract
Wild birds share with humans the capacity for moving fast over large distances. During migratory movements, birds carry pathogens that can be transmitted between species. One of these concerning pathogens is Mycobacterium spp. A necropsy was performed in a grey heron (Ardea cinerea) that had been medically treated for a polyarthritic process. Grossly, firm white-yellowish nodules of various size, resembling granulomas, were observed in right carpal joint, both patellar joints, neck musculature, palate, pharynx, larynx, nasal sinuses, pericardial sac, air sacs, proventriculus and intestinal serosa, pancreas, kidneys, adrenal glands, and oviduct. Microscopically, these lesions were composed of multinucleated giant cells, large macrophages, and lymphocytes, with a central zone of necrosis and in some cases with peripheral fibrosis. Acid-fast bacilli were detected within these lesions. Lesions were cultured and Mycobacterium avium subsp. avium was identified. To the best of our knowledge this is the first description of mycobacteriosis in grey herons. Although the grey heron is currently considered a least-concern species, avian mycobacteriosis remains a threat on the conservation management of endangered avian species, and constitutes a public health concern as well.

PMID: 24283143 [PubMed - in process]

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